Translating for growth

Phototropism: translating light into directional growth.

Phototropism allows plants to align their photosynthetic tissues with incoming light. The direction of incident light is sensed by the phototropin family of blue light photoreceptors (phot1 and phot2 in Arabidopsis), which are light-activated protein kinases. The kinase activity of phototropins and phosphorylation of residues in the activation loop of their kinase domains are essential for the ...

Translating Literary Types

Translating Logics for Coalgebras

This paper shows, that three di erent types of logics for coalgebras are institutions. The logics di er regarding the presentation of their syntax. In the rst framework, abstract behavioural logic, one has a syntax-free representation of behavioural properties. We then turn to coalgebraic logic, the syntax of which is given as an initial algebra. The last framework, which we consider, is coalge...

Translating simulation approaches for immunology

This thesis presents a novel set of guidelines to convert between simulation modelling approaches, namely, Ordinary Differential Equations (ODEs), System Dynamics (SD) and Agent-based Modelling and Simulation (ABMS). In our literature review we identify a gap in establishing translation techniques between these approaches. We therefore focus our research in developing these techniques and asses...

Translating Polygenic Analysis for Prevention

There are no easy answers in complex disease genetics. Common, chronic health conditions such as obesity and heart disease are influenced by many genetic variants scattered across the genome, with each variant making small contributions to risk. Ever-larger genome-wide association studies (GWAS) are uncovering more and more of these variants. For many diseases and disease-related traits, discov...